Sandostatin(r) is long-acting analogue of somatostatin that is a naturally occurring peptide with biologic actions which are inhibitory in nature on the gastrointestinal tract. Somatostatin is widely distributed throughout the human
gastrointestinal
system. There it is found in neurons and fibers of both the submucosal and myenteric plexus and pancreas, and also in the stomach, gut, and pancreatic islets. It appears to function as a hormone, as well as both a paracrine and neurotransmitter.
We
conducted retrospective review of 37 patients with 15 enterocutaneous fistula, 19 pancreatitis, 1 dumping syndrome, and 2 diarrhea to sec effect of Sandostatin(r). Sandostatin(r) was administered subcutaneously at dose of 0.05mg every 8 hours.
The
amount of the enterocutaneous fistula dramaticall decreased by over 50% with in 24 hours. 60% of the case were cured without surgical intervention.
Almost all cases of pancreatitis including complicated case showed symptomatic and radiologicl improvement as well as serologic improvement of pancreatic enzymes, but we didn't haye enough cases to compare with classical conservative treatments.
Also we
treated 1 case of dumping syndrome and 2 cases of massive diarrhea satisfactorily.
Novel drugs. Sandostatin(r) gave us very good results in car fully selected cases.
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